Symptoms
Symptoms are identical to HS, they range from asymptomatic to severe.
Abnormality revolves around spectrin leading to skeletal changes which can cause the cell to fragment
Asymptomatic group (majority)
Haemolytic anaemia group
Haematological Profile
More than 25% elliptocytes are required for a diagnosis of elliptocytosis
Because erythropoiesis is compensated for, polychromasia is present
Treatment
Splenectomy, if more than 5 years old (corrects anaemia due to haemolysis, still more susceptible to infection (vaccination becomes even more essential) and the haemolysis is severe.
