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Category: Nephrology

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Alport’s syndrome overview

Published: July 17, 2009. Updated: July 27, 2009

Alport's syndrome is an X-linked hereditary nephritis sometimes accompanied by sensorineural hearing loss.

Clinical suspicion

Hematuria in male and family history of males progressing to end stage renal disease. Females are rare.


Pathology shows mild mesangial hypercellularity without immune deposits but with widespread splitting and lamination of the glomerular basement membrane.

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