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Triamterene overview

Published: June 20, 2009. Updated: August 19, 2019

Triamterene is a potassium-sparing diuretic used in combination with thiazide diuretics for the treatment of hypertension and edema.

Pregnancy Category B

Drug classes

  • Diuretic: Potassium Sparing

Brand Names (US)

  • Dyrenium
  • Dosing

  • 100 mg twice daily, orally after meals. The dose should be titrated as required. The total daily dosage should not exceed 300 mg (similar to aldosterone).
  • Therapeutic actions

    Inhibits sodium reabsorption from the renal distal tubule (collecting duct), causing loss of sodium and water and retention of potassium.


    Edema associated with CHF, nephrotic syndrome, hepatic cirrhosis; steroid-induced edema, edema from secondary hyperaldosteronism (alone or with other diuretics for added diuretic or antikaliuretic effects)


    Contraindicated in the presence of allergy to triamterene, hyperkalemia, renal disease (except nephrosis), liver disease, lactation.

    Use caution in the presence of diabetes mellitus, pregnancy.

    Adverse effects

    • Electrolyte abnormalities: Hyperkalemia, hypercalcemia
    • CNS: Headache, drowsiness, fatigue, weakness
    • GI: Nausea, anorexia, vomiting, dry mouth, diarrhea
    • Hematologic: Blood dyscrasias
    • GU: Renal stones, intersititial nephritis
    • Dermatologic: Rash, photosensitivity

    Previous: Bumetanide

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