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Category: Cardiology | Pathology

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Troponin overview

Published: June 21, 2009. Updated: August 17, 2009

Troponin is a protein that confers calcium sensitivity to muscle cells.

Diagnostic use

Certain subtypes of troponin (Troponin I and T) are quite specific to the heart muscle (myocardium) and are measured in blood to differentiate between unstable angina pectoris and myocardial infarction in patients with chest pain.

Elevation due to cardiac conditions:

  • Cardiac amyloidosis
  • Cardiac contusion
  • Cardiac surgery and heart transplant
  • Defibrillation
  • Closure of atrial septal defects
  • Coronary vasospasm
  • Dilated cardiomyopathy
  • Heart failure
  • Hypertrophic cardiomyopathy
  • Myocarditis
  • Percutaneous coronary intervention
  • Radiofrequency ablation
  • Supraventricular tachycardia

Elevation due to non-cardiac conditions:

  • Critical illness, e.g. sepsis
  • High-dose chemotherapy
  • Primary pulmonary hypertension
  • Pulmonary embolism
  • Renal failure
  • Subarachnoid hemorrhage
  • Scorpion venom
  • Stroke
  • Very heavy exercise (marathon)

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