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Back to 1st Generation Cephalosporins

Brand Name: Ceclor
Name: Cefaclor

Pregnancy Category B

Drug classes

Cephalosporin (first generation)

Mechanism of action of Ceclor
Bactericidal:  inhibits synthesis of bacterial cell wall, causing cell death.

Indications of Ceclor

  • Lower respiratory tract infections caused by Streptococcus pneumoniae, Haemophilus influenzae, S. pyogenes
  • Upper respiratory infections caused by S. pyogenes
  • Dermatologic infections caused by Staphylococcus aureus, S. pyogenes
  • UTIs caused by E. coli, P. mirabilis, Klebsiella, coagulase-negative staphylococci
  • Otitis media caused by S. pneumoniae, H. influenzae, S. pyogenes, staphylococci

Unlabeled use: acute uncomplicated UTI in select patients, single 2-g dose

Contraindications of Ceclor

  • Allergy to cephalosporins or penicillins
  • Renal failure
  • Lactation

Adverse effectsof Ceclor

  • CNS: Headache, dizziness, lethargy, paresthesias
  • GI: Nausea, vomiting, diarrhea, anorexia, abdominal pain, flatulence, pseudomembranous colitis, liver toxicity
  • Hematologic: Bone marrow depression
  • GU: Nephrotoxicity
  • Hypersensitivity: Ranging from rash, fever to anaphylaxis; serum sickness reaction
  • Other: Superinfections

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