Back to 1st Generation Cephalosporins

Brand Name: Ceclor
Name: Cefaclor

Pregnancy Category B

Drug classes

Antibiotics
Cephalosporin (first generation)

Mechanism of action of Ceclor
Bactericidal: inhibits synthesis of bacterial cell wall, causing cell death.

Indications of Ceclor

Lower respiratory tract infections caused by Streptococcus pneumoniae, Haemophilus influenzae, S. pyogenes
Upper respiratory infections caused by S. pyogenes
Dermatologic infections caused by Staphylococcus aureus, S. pyogenes
UTIs caused by E. coli, P. mirabilis, Klebsiella, coagulase-negative staphylococci
Otitis media caused by S. pneumoniae, H. influenzae, S. pyogenes, staphylococci

Unlabeled use: acute uncomplicated UTI in select patients, single 2-g dose

Contraindications of Ceclor

Adverse effectsof Ceclor

CNS: Headache, dizziness, lethargy, paresthesias
GI: Nausea, vomiting, diarrhea, anorexia, abdominal pain, flatulence, pseudomembranous colitis, liver toxicity
Hematologic: Bone marrow depression
GU: Nephrotoxicity
Hypersensitivity: Ranging from rash, fever to anaphylaxis; serum sickness reaction
Other: Superinfections

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