Pregnancy Category B
Mechanism of action of Cefaclor
Bactericidal: inhibits synthesis of bacterial cell wall, causing cell death.
Indications of Cefaclor
- Lower respiratory tract infections caused by Streptococcus pneumoniae, Haemophilus influenzae, S. pyogenes
- Upper respiratory infections caused by S. pyogenes
- Dermatologic infections caused by Staphylococcus aureus, S. pyogenes
- UTIs caused by E. coli, P. mirabilis, Klebsiella, coagulase-negative staphylococci
- Otitis media caused by S. pneumoniae, H. influenzae, S. pyogenes, staphylococci
Unlabeled use: acute uncomplicated UTI in select patients, single 2-g dose
Contraindications of Cefaclor
- Allergy to cephalosporins or penicillins
- Renal failure
Adverse effectsof Cefaclor
- CNS: Headache, dizziness, lethargy, paresthesias
- GI: Nausea, vomiting, diarrhea, anorexia, abdominal pain, flatulence, pseudomembranous colitis, liver toxicity
- Hematologic: Bone marrow depression
- GU: Nephrotoxicity
- Hypersensitivity: Ranging from rash, fever to anaphylaxis; serum sickness reaction
- Other: Superinfections
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