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Cefuroxime axetil

Ceftin, cefuroxime sodium
Kefurox, Zinacef

Pregnancy Category B

Drug classes

Antibiotics
Cephalosporin (second generation)

Mechanism of action
Bactericidal:  inhibits synthesis of bacterial cell wall, causing cell death.

Indications

Oral (Cefuroxime Axetil)

  • Pharyngitis, tonsilitis caused by S. pyogenes
  • Otitis media caused by S. pneumoniae, H. influenzae, M. catarrhalis, S. pyogenes
  • Lower respiratory tract infections caused by S. pneumoniae, H. parainfluenxae, H. influenzae
  • UTIs caused by E. coli, K. pneumoniae
  • Dermatologic infections, including impetigo caused by S. aureus, S. pyogenes

Parenteral (Cefuroxime Sodium)

  • Lower respiratory tract infections caused by S. pneumoniae, S. aureus, E. coli, Klebsiella, H. influenzae, S. pyogenes
  • Dermatologic infections caused by S. aureus, S. pyogenes, E. coli, Klebsiella, Enterobacter
  • UTIs caused by E. coli, Klebsiella
  • Uncomplicated and disseminated gonorrhea caused by N. gonorrhoea
  • Septicemia caused by S. pneumoniae, S. aureus, E. coli, Klebsiella, H. influenzae
  • Meningitis caused by S. pneumoniae, H. influenzae, S. aureus, N. meningitidis
  • Bone and joint infections caused by S. aureus
  • Perioperative prophylaxis
     

Contraindications

  • Allergy to cephalosporins or penicillins
  • Renal failure
  • Lactation

Adverse effects

  • CNS: Headache, dizziness, lethargy, paresthesias
  • GI: Nausea, vomiting, diarrhea, anorexia, abdominal pain, flatulence, pseudomembranous colitis, liver toxicity
  • Hematologic: Bone marrow depression: decreased WBC, decreased platelets, decreased Hct
  • GU: Nephrotoxicity
  • Hypersensitivity: Ranging from rash to fever to anaphylaxis, serum sickness reaction
  • Local: Pain, abscess at injection site; phlebitis, inflammation at IV site
  • Other: Superinfections, disulfiram-like reaction with alcohol

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