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Back to 2nd Generation Cephalosporins



Pregnancy Category B

Drug classes

Cephalosporin (second generation)

Mechanism of action
Bactericidal:  inhibits synthesis of bacterial cell wall, causing cell death.


  • Pharyngitis/tonsillitis caused by Streptococcus pyogenes
  • Secondary bacterial infection of acute bronchitis and exacerabation of chronic bronchitis caused by S. pneumoniae, H. influenzae, M. catarrhalis
  • Pneumonia caused by S. pneumoniae, H. influenzae
  • Dermatologic infections caused by Staphylococcus aureus, S. pyogenes
  • Urinary tract infections caused by E. coli, Staphylococcus saprophyticus 
  • Otitis media caused by S. pneumoniae, H. influenzae, M. catarrhalis, S. pyogenes


  • Allergy to cephalosporins or penicillins
  • Renal failure
  • Lactation

Adverse effects

  • CNS: Headache, dizziness, lethargy, paresthesias
  • GI: Nausea, vomiting, diarrhea, anorexia, abdominal pain, flatulence, pseudomembranous colitis, liver toxicity
  • Hematologic: Bone marrow depression
  • GU: Nephrotoxicity
  • Hypersensitivity: Ranging from rash to fever to anaphylaxis, serum sickness reaction
  • Local: Pain, abscess at injection site; phlebitis, inflammation at IV site
  • Other: Superinfections

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