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Back to 3rd Generation Cephalosporins

Cefixime

Suprax

Pregnancy Category B

Drug classes

Antibiotics
Cephalosporin (third generation)

Mechanism of action
Bactericidal:  inhibits synthesis of bacterial cell wall, causing cell death.

Indications

  • Uncomplicated UTIs caused by E. coli, P. mirabilis
  • Otitis media caused by H. influenzae (beta-lactamase positive and negative strains), Moraxella catarrhalis, S. pyogenes
  • Pharyngitis, tonsillitis caused by S. pyogenes
  • Acute bronchitis and acute exacerbations of chronic bronchitis caused by S. pneumoniae, H. influenzae (beta-lactamase positive and negative strains)
  • Uncomplicated gonorrhea caused by Neisseria gonorrhoeae

Contraindications

  • Allergy to cephalosporins or penicillins
  • Renal failure
  • Lactation

Adverse effects

  • CNS: Headache, dizziness, lethargy, paresthesias
  • GI: Nausea, vomiting, diarrhea, anorexia, abdominal pain, flatulence, pseudomembranous colitis, liver toxicity
  • Hematologic: Bone marrow depression
  • GU: Nephrotoxicity
  • Hypersensitivity: Ranging from rash to fever to anaphylaxis, serum sickness reaction
  • Other: Superinfections, disulfiram-like reaction with alcohol

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