Pregnancy Category C
Mechanism of action
Bactericidal; interferes with DNA replication in susceptible gram-negative bacteria preventing cell reproduction.
For the treatment of infections caused by susceptible gram-negative
bacteria, including E. coli, P. mirabilis, K. pneumoniae, Enterobacter
cloacae, P. vulgaris, P. rettgeri, M. morganii, P. aeruginosa, Citrobacter freundii, S. aureus, S. epidermidis, group D streptococci
Unlabeled use: effective in patients with cystic fibrosis who have pulmonary exacerbations
- The presence of allergy to ciprofloxacin, norfloxacin,
Use caution in the presence of renal dysfunction, seizures.
- CNS: Headache, dizziness, insomnia, fatigue, somnolence, depression, blurred vision
- GI: Nausea, vomiting, dry mouth, diarrhea, abdominal pain
- Hematologic: Elevated BUN, SGOT, SGPT, serum creatinine and alkaline phosphatase; decreased WBC, neutrophil count, hematocrit
- Other: Fever, rash
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