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Name: Clotrimazole

Pregnancy Category C (troche)
Pregnancy Category B (topical, vaginal)

Drug classes

  • Antifungal

Therapeutic actions

Fungicidal and fungistatic: binds to fungal cell membrane with a resultant change in membrane permeability, allowing leakage of intracellular components, causing cell death.

Indications

  1. Treatment of oropharyngeal candidiasis (troche)
  2. Local treatment of vulvovaginal candidiasis (moniliasis; vaginal preparations)
  3. Topical treatment of tinea pedia, tinea cruris, tinea corporis due to Trichophyton rubrum, Trichophyton mentagrophytes, Epidermophyton floccosum, Microsporum canis; candidiasis due to Candida albicans; tinea versicolor due to Microsporum furfur (topical preparations)

Contraindications/cautions

Allergy to clotrimazole or components used in preparation

Adverse effects

Troche

  • GI: Nausea, vomiting, abnormal liver function tests

Vaginal

  • GI: Lower abdominal cramps, bloating
  • GU: Slight urinary frequency; burning or irritation in the sexual partner
  • Dermatologic: Skin rash

Topical

  • Local: Erythema, stinging, blistering, peeling, edema, pruritus, urticaria, general skin irritation

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