Back to Infections Drug Index

Back to Antifungals

Name: Clotrimazole

Pregnancy Category C (troche)
Pregnancy Category B (topical, vaginal)

Drug classes

  • Antifungal

Therapeutic actions

Fungicidal and fungistatic: binds to fungal cell membrane with a resultant change in membrane permeability, allowing leakage of intracellular components, causing cell death.


  1. Treatment of oropharyngeal candidiasis (troche)
  2. Local treatment of vulvovaginal candidiasis (moniliasis; vaginal preparations)
  3. Topical treatment of tinea pedia, tinea cruris, tinea corporis due to Trichophyton rubrum, Trichophyton mentagrophytes, Epidermophyton floccosum, Microsporum canis; candidiasis due to Candida albicans; tinea versicolor due to Microsporum furfur (topical preparations)


Allergy to clotrimazole or components used in preparation

Adverse effects


  • GI: Nausea, vomiting, abnormal liver function tests


  • GI: Lower abdominal cramps, bloating
  • GU: Slight urinary frequency; burning or irritation in the sexual partner
  • Dermatologic: Skin rash


  • Local: Erythema, stinging, blistering, peeling, edema, pruritus, urticaria, general skin irritation

Are you a Doctor, Pharmacist, PA or a Nurse?

Join the Doctors Lounge online medical community

  • Editorial activities: Publish, peer review, edit online articles.

  • Ask a Doctor Teams: Respond to patient questions and discuss challenging presentations with other members.

Doctors Lounge Membership Application

Tools & Services: Follow DoctorsLounge on Twitter Follow us on Twitter | RSS News | Newsletter | Contact us