Brand Name: Diflucan
Pregnancy Category C
Drug classes of Diflucan
Therapeutic actions of Diflucan
Diflucan is a highly selective inhibitor of fungal cytochrome
P-450 sterol C-14
alpha-demethylation. This decreases ergosterol synthesis which is the principal sterol in fungal cell membranes, thus inhibiting cell membrane formation.
Indications of Diflucan
- Vaginal candidiasis (vaginal yeast infections due to Candida).
- Oropharyngeal and esophageal
candidiasis. In open noncomparative studies of relatively
small numbers of patients, Diflucan was also effective for the treatment of Candida
urinary tract infections, peritonitis, and systemic Candida infections including candidemia,
disseminated candidiasis, and pneumonia.
- Cryptococcal meningitis.
- Prophylaxis. Diflucan is also indicated to decrease the incidence of candidiasis in patients undergoing bone marrow transplantation who receive cytotoxic chemotherapy and/or radiation therapy.
Specimens for fungal culture and other relevant laboratory studies (serology, histopathology) should be obtained prior to therapy to isolate and identify causative organisms. Therapy may be instituted before the results of the cultures and other laboratory studies are known; however, once these results become available, anti-infective therapy should be adjusted accordingly.
Contraindications/cautions of Diflucan
- hypersensitivity to Diflucan or to any of its excipients. Caution should be used in prescribing Diflucan to patients with hypersensitivity to other azoles.
- Concomitant adminstration with terfanidine, cisapride or astemizole.
- Patients with liver failure.
- Diflucan should be administered with caution to patients with these potentially proarrhythmic conditions.
Adverse effects of Diflucan
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toxicity, including fatalities primarily in patients with serious underlying medical
conditions. Diflucan hepatotoxicity has usually, but not always, been reversible on discontinuation of therapy.
malignancy), these have rarely resulted in a fatal outcome. Patients who develop rashes during treatment with Diflucan should be monitored closely and the drug discontinued if lesions progress.
involved seriously ill patients with multiple confounding risk factors, such as structural heart disease, electrolyte abnormalities and concomitant medications that may have been contributory. Diflucan should be administered with caution to patients with these potentially proarrhythmic conditions.
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