Name: Magnesium sulfate
Pregnancy Category A
Cofactor of many enzyme systems involved in neurochemical transmission and muscular excitability; prevents or controls convulsions by blocking neuromuscular transmission; attracts/retains water in the intestinal lumen and distends the bowel to promote mass movement and relieve constipation.
- Hypomagnesemia, replacement therapy (IV)
- Toxemia/eclampsia/nephritis (IV, IM)
- Short-term treatment of constipation (PO)
- Evacuation of the colon for rectal and bowel examinations (PO)
- Unlabeled use: inhibition of premature labor (parenteral)
Contraindicated in the presence of allergy to magnesium products;
block, myocardial damage; abdominal pain, nausea, vomiting or other
symptoms of appendicitis; acute surgical abdomen, fecal impaction,
intestinal and biliary tract obstruction, hepatitis. Do not give
h preceding delivery because of risk of magnesium toxicity in the neonate.
Use caution in the presence of renal insufficiency.
- CNS: Weakness, dizziness, fainting, sweating (PO)
- GI: Excessive bowel activity, perianal irritation (PO)
- CV: Palpitations (PO)
- Metabolic: Magnesium intoxication (flushing, sweating, hypotension, depressed relfexes, flaccid paralysis,hypothermia, circulatory collapse, cardiac and CNS depression-parenteral); hypocalcemia with tetany (secondary to treatment of eclampsia-parenteral)
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