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Date of last update: 10/04/2017.

Forum Name: Neurology Topics

Question: Neurotoxicity hx and Retin-A

 redwingedblackbird - Sat Aug 11, 2007 8:12 pm


I am a 31 year old female who is slowly recovering from medication induced neurotoxicity [for example, many rounds of Flagyl, Vancomycin, isoniazid, nitrous oxide with extensive dental work].

My related diagnoses are: 2003 - pos. ppd 16mm induration, 2004 - hip surgery with C.diff, 2005 - gastroparesis, 2006 - dysautonomia and postural orthostatic tachycardia syndrome, 1995/2006 - B12 deficiency.

Currently I experience CNS deficits/symptoms and have been advised to avoid all neurotoxic meds and supplements.

Question 1: is it inadvisable to use Retin-A micro topical acne gel with my neurologically challenged history?

Question 2: Do you have any suggestions regarding neuro-supportive supplements such as acetyl L-carnitine, alpha lipoic acid, NAC?

Current meds: Propranolol, Wellbutrin, B12 injections, Singulair.

Thank you so much, RWBB.
 Dr. Chan Lowe - Fri Aug 24, 2007 5:05 pm

User avatar Hi RWBB,

Most of the literature suggests that oral retin A can be associated with neurotoxicity. There are also a few reports of topical retin A being associated with neurotoxicity as well. This link has not been as well established as the oral route; however, it does seem possible in some cases for toxicity to occur.

If you choose to use this product I would recommend you be very cautious and if any symptoms begin to appear you should discontinue its use immediately.

Regarding neurologically supportive supplements I am not knowledgeable enough about them to say with any confidence whether they work or not. I would add, though, that vitamin B12 deficiency can cause significant neurological effects so be sure keep your levels up.

Best wishes.

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