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Sunday June 16, 2002 10:25 PM GMT

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Active oxygen species have long been known to be mutagenic, hence playing a role in cancer formation.

 
 

 
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Free Radicals; Types & Dangers
Antioxidants, classification and chemistry

 
   
 
     

Measuring oxidative DNA damage:

Quantitatively, the 8-hydroxylated derivative of dG is one of the most prevalent oxidised product of DNA generated in vitro under physiological conditions. This lesion also functions as a sensitive biomarker of oxidative DNA damage in vivo (Aruoma et al. 1989). This has been proved in studies using ionising radiation on human cell cultures, whole animals or bacteria. Further, the excretion of 8-hydroxy-G is correlated with age, metabolic rate, caloric intake, and antioxidant intake of diet.

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