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Melphalan, L-PAM, L-Sarcolysin, Phenylalanine mustard

Pregnancy Category D

Drug classes

Alkylating Agent

Mechanism of action

A derivative of mechlorethamine that inhibits DNA and RNA synthesis via formation of carbonium ions; cross-links strands of DNA.


Palliative treatment of:

  • Multiple Myeloma
  • Ovarian adenocarcinoma
  • Rhabdomyosarcoma
  • Neuroblastoma
  • Breast cancer


  • Hypersensitivity to the drug
  • Myelosuppression
  • Pregnancy

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