Back to Alkylating Agents
Alkeran
Melphalan, L-PAM, L-Sarcolysin, Phenylalanine mustard
Pregnancy Category D
Drug classes
Antineoplastic
Alkylating Agent
Mechanism of action
A derivative of mechlorethamine that inhibits DNA and RNA synthesis via formation of carbonium ions; cross-links strands of DNA.
Indications
Palliative treatment of:
- Multiple Myeloma
- Ovarian adenocarcinoma
- Rhabdomyosarcoma
- Neuroblastoma
- Breast cancer
Contraindications
- Hypersensitivity to the drug
- Myelosuppression
- Pregnancy
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