CDDP, Platinol, Platinol-AQ
Pregnancy Category D
Mechanism of action
Cytotoxic: heavy metal that inhibits cell replication; cell cycle nonspecific.
- Metastatic testicular tumors: combination therapy with bleomycin sulfate and vinblastine sulfate after surgery or radiotherapy
- Metastatic ovarian tumors: as single therapy
in resistant patients or in
combination therapy with doxorubicin after surgery or radiotherapy
- Advanced bladder cancer: single agent for transitional cell bladder cancer no longer amenable to surgery or radiotherapy
- Allergy to cisplatin
- Platinum-containing products
- Hematopoietic depression
- Impaired renal function
- Hearing impairment
- CNS: Ototoxicity, peripheral neuropathies, seizures, loss of taste
- GI: Nausea, vomiting, anorexia
- Hematologic: Leukopenia, thrombocytopenia, anemia, hypomagnesemia, hypocalcemia, hypokalemia, hypophosphatemia, hyperuricemia
- GU: Nephrotoxicity, dose limiting
- Hypersensitivity: Anaphylactic-like reactions, facial edema, bronchoconstriction, tachycardia, hypotension (treat with epinephrine, corticosteroids, antihistamines)
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