Actinomycin D, ACT
Pregnancy Category C
Mechanism of action
Cytotoxic: inhibits synthesis of messenger RNA, causing cell death; cell cycle nonspecific.
- Wilms' tumor
- Netastatic and nonmetastatic choriocarcinoma
- Ewing's sarcoma
- Sarcoma botryoides
- Nonseminomatous testicular carcinoma
- Potentiation of effects of radiation therapy
- Allergy to dactinomycin
- Herpes zoster (severe, generalized disease and death could result)
Use caution in the presence of bone marrow suppression, radiation therapy.
- GI: Cheilitis, dysphagia, esophagitis, ulcerative stomatitis, pharyngitis, anorexia, abdominal pain, diarrhea, GI ulceration, proctitis, nausea, vomiting, hepatic abnormalities
- Hematologic: Anemia, aplastic anemia, agranulocytosis, leukopenia, thrombocytopenia, pancytopenia, reticulopenia
- Dermatologic: Alopecia, skin eruptions, acne, erythema, increased pigmentation of GU renal abnormalities
- Local: Tissue necrosis at sites of extravasation
- Other: Malaise, fever, fatigue, lethargy, myalgia, hypocalcemia, death, increased incidence of second primary tumors when used with radiation
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