Back to Mitotic inhibitors
Name: Vinblastine Sulfate
Pregnancy Category D
Drug classes
- Mitotic inhibitor
- Antineoplastic agent
Therapeutic actions
Affects cell energy production required for mitosis and interferes with nucleic acid synthesis; has antimitotic effect and causes abnormal mitotic figures.
Indications
Palliative treatment for generalized Hodgkin's disease (stages III and IV), lymphocytic lymphoma, histiocytic lymphoma, mycosis fungoides, advance testicular carcinoma, Kaposi's sarcoma, Letterer-Siwe disease
Palliative treatment of choriocarcinoma, breast cancer unresponsive to other therapies
Hodgkin's disease (advanced) alone or in combination therapies
Advanced testicular germinal-cell cancers alone or in combination therapy
Contraindications/cautions
Contraindicated in the presence of allergy to vinblastine, leukopenia, acute infection, pregnancy, lactation.
Use caution in the presence of liver disease.
Adverse effects
- CNS: Numbness, paresthesias, peripheral neuritis, mental depression, loss of deep tendon reflexes, headache, seizures, malaise, weakness, dizziness
- GI: Nausea, vomiting, pharyngitis, vesiculation of the mouth, ileus, diarrhea, constipation, anorexia, abdominal pain, rectal bleeding, hemorrhagic enterocolitis
- Hematologic: Leukopenia
- GU: Aspermia
- Dermatologic: Topical epilation (loss of hair), vesiculation of the skin
- Local: Local cellulitis, phlebitis, sloughing of the skin if extravasation occurs
- Other: Pain in tumor site Pregnancy Category D
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