Name: Vinblastine Sulfate
Pregnancy Category D
- Mitotic inhibitor
- Antineoplastic agent
Affects cell energy production required for mitosis and interferes with nucleic acid synthesis; has antimitotic effect and causes abnormal mitotic figures.
Palliative treatment for generalized Hodgkin's disease (stages III and IV), lymphocytic lymphoma, histiocytic lymphoma, mycosis fungoides, advance testicular carcinoma, Kaposi's sarcoma, Letterer-Siwe disease
Palliative treatment of choriocarcinoma, breast cancer unresponsive to other therapies
Hodgkin's disease (advanced) alone or in combination therapies
Advanced testicular germinal-cell cancers alone or in combination therapy
Contraindicated in the presence of allergy to vinblastine, leukopenia, acute infection, pregnancy, lactation.
Use caution in the presence of liver disease.
- CNS: Numbness, paresthesias, peripheral neuritis, mental depression, loss of deep tendon reflexes, headache, seizures, malaise, weakness, dizziness
- GI: Nausea, vomiting, pharyngitis, vesiculation of the mouth, ileus, diarrhea, constipation, anorexia, abdominal pain, rectal bleeding, hemorrhagic enterocolitis
- Hematologic: Leukopenia
- GU: Aspermia
- Dermatologic: Topical epilation (loss of hair), vesiculation of the skin
- Local: Local cellulitis, phlebitis, sloughing of the skin if extravasation occurs
- Other: Pain in tumor site Pregnancy Category D
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