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Date of last update: 10/21/2017.

Forum Name: Skin Cancer

Question: Side Effects with Efudex

 rustygates - Fri Oct 30, 2009 8:57 am

Two weeks ago, I was prescribed generic of Efudex cream for pre-cancerous skin conditions on both arms. On the 3rd day of use, I developed severe diarrhea, suffering 4 to 5 episodes per day. No other symptoms, no vomiting or fever, feel fine. Stopped using the cream after 6 days after realizing this might be a side effect. Dermatology PA insists this can't possibly be a reaction, must be another cause for the diarrhea, which is mostly water at this point. Am keeping hydrated. Should I take immodium, any side effects or interaction with current medications? Since I've never had a history of diarrhea, I do believe this is a serious side effect of this drug. Opinion please?
 Dr.M.jagesh kamath - Mon Nov 02, 2009 10:59 pm

User avatar Hello,While the diarrhoea may be unrelated to efudex,there are reported cases of people with an enzyme deficiency DPD react by accumulating the drug even on external application leading to toxicity.These include diarrhoea a manifestation as grade1 toxicity.You must get your blood examined to rule this out just to be sure.Do consult your doctor who would order for this rare but realistic possiblity.Best wishes.

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