Cancer Chemotherapy Regimen for Breast Cancer
AC/ACMF breast(17,18) _________________________________________________________________ adriamycin...... 40 mg/sqm IV day 1. cytoxan......... 1 g/sqm IV day 1. FREQUENCY....... Repeat cycle every 21 days. adriamycin...... 40 mg/sqm IV day 1. cytoxan......... 1 g/sqm IV day 1. methotrexate.... 30 to 40 mg/sqm IV days 21, 28 and 35. fluorouracil.... 400 to 600 mg/sqm IV days 21, 28 and 35. FREQUENCY....... Repeat cycle every 42 days. 17. Boston B, et.al. Combination vs. combination sequential non-hormonal chemotherapy in advanced breast cancer. Proc Am Soc Clin Oncol 17:247, 1976. reference... Kennealey GT. Boston B. Mitchell MS. Knobf MK. Bobrow SN. Pezzimenti JF. Lawrence R. Bertino JR. Combination chemotherapy for advanced breast cancer: two regimens containing adriamycin. Cancer. 42(1):27-33, 1978 Jul. abstract... Forty-eight women with advanced metastatic carcinoma of the breast were treated with one of two combination chemotherapy regimens: 1) adriamycin and cyclophosphamide or 2) adriamycin, cyclophosphamide, methotrexate and 5-fluorouracil. The response rate in the two-drug treatment group was 50% and in the four-drug treatment group, 55%. The median duration of response was ten months in both treatment groups. Dramatic responses were seen in patients with visceral metastases. Patients who responded to chemotherapy had a significantly longer survival than nonresponders (p less than 0.01). The long interval between adriamycin doses (six weeks) in the four drug regimen did not adversely effect the response rate--an important finding in view of the dose-related cardiac toxicity of this agent.
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