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Cancer Chemotherapy Regimen for Breast Cancer

 CMFVP                                                  breast(23)
  cytoxan......... 400 mg/sqm IV day 1.
  methotrexate.... 30 mg/sqm IV days 1 and 8.
  fluorouracil.... 400 mg/sqm IV days 1 and 8.
  vincristine..... 1 mg IV days 1 and 8.
  prednisone...... 20 mg orally four times daily on days 1 to 7.
  FREQUENCY....... Repeat cycle every 28 days.

    Smalley RV.  Carpenter J.  Bartolucci A.  Vogel C.  Krauss S. 
    A comparison of cyclophosphamide, adriamycin, 5-fluorouracil 
    (CAF) and cyclophosphamide, methotrexate, 5-fluorouracil, 
    vincristine, prednisone (CMFVP) in patients with metastatic 
    breast cancer: a Southeastern Cancer Study Group project. 
    Cancer.  40(2):625-32, 1977 Aug. 
    In an ongoing prospective randomized study, 113 evaluable 
    patients have received either a three-drug combination that 
    included cyclophosphamide, Adriamycin and 5-fluorouracil (CAF) 
    or a five-drug combination including cyclophosphamide, 
    methotrexate, 5-fluorouracil, vincristine and prednisone 
    (CMFVP) given intermittently 1 week out of 4. Responses (64%), 
    median duration of response (32 weeks), and median duration of 
    disease control (32 weeks) achieved with CAF were superior to 
    those achieved with CMFVP (37%, 22 weeks, 17 weeks, 
    respectively). Morbidity secondary to CAF was significant, 
    with nausea and vomiting, malaise, total alopecia, and 
    granulocytopenia being the main features. 

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