Cancer Chemotherapy Regimen for Colon Cancer
MOF-S colon(49) _________________________________________________________________ semustine....... 30 mg/sqm/day orally on days 1 to 5 inclusive. vincristine..... 1 mg IV day 1 and day 35 (5 weeks). fluorouracil.... 300 mg/sqm/day IV on days 1 to 5 and on days 35 to 40, inclusive. streptozotocin.. 500 mg/sqm IV on day 1 and weekly thereafter. FREQUENCY....... Repeat cycle every 70 days (10 weeks). reference... Kemeny N. Yagoda A. Braun D Jr. Golbey R. Therapy for metastatic colorectal carcinoma with a combination of methyl-CCNU, 5-fluorouracil vincristine and streptozotocin (MOF-Strep). Cancer. 45(5):876-81, 1980 Mar 1. abstract... Seventy-seven previously untreated patients with measurable metastatic colorectal carcinoma were treated with a combination of methyl-CCNU, 5-fluorouracil (5-FU), vincristine and streptozotocin (MOF-Strep). The treatment schedule consisted of methyl-CCNU, 30 mg/m2 for 5 consecutive days q 10 weeks; 5-FU, 300 mg/m2 IV for five consecutive days q 5 weeks; vincristine, 1 mg IV q 5 weeks; and streptozotocin, 500 mg/m2 IV weekly. Two (3%) patients achieved complete remission (CR); 22 (29%) patients, a partial remission (PR); and 13 (18%) patients, a minor remission (MR). The median duration of remission was eight months (range, 4-25+months) for patients obtaining CR/PR status, and six months (range, 4-15 months) for MR status. The median survival time was 14 months for patients achieving CR/PR versus seven months for non responders. Comparison with a previous study of MOF at Memorial Sloan-Kettering Cancer Center, showed that the MOF-Strep combination produced a significant (P = 0.004) increase in the number of complete and partial remissions, 32% versus 11%, and in survival, 11 versus 9 months, (P = 0.003), respectively.
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