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Cancer Chemotherapy Regimen for Non-small Cell Lung Cancer

  bleomycin....... 30 U IV day 2, then weekly times 6 weeks.
  adriamycin...... 40 mg/sqm IV day 1, then every 4 weeks.
  lomustine....... 65 mg/sqm orally day 1, then every 8 weeks.
  vincristine..... 0.75 to 1.0 mg/sqm IV day 2, then weekly times 
                   6 weeks.
  mechlorethamine. 8 mg/sqm IV day 1, then every 4 weeks.
  FREQUENCY....... Specified above.

    Livingston RB.  Fee WH.  Einhorn LH.  Burgess MA.  Freireich 
    EJ.  Gottlieb JA.  Farber MO. BACON (bleomycin, adriamycin, 
    CCNU, oncovin and nitrogen mustard) in squamous lung cancer. 
    Experience in fifty patients. Cancer.  37(3):1237-42, 1976 
    Fifty patients with inoperable squamous carcinoma of the lung. 
    38 with extensive, and 12 with limited disease, were treated 
    with BACON. Tumor regression greater than 50% was observed in 
    17 patients (45%) with extensive, and four patients (33%) with 
    limited disease. Stabilization of disease for greater than or 
    equal to 8 weeks was seen in four extensive and eight limited 
    patients, and had the same prognostic importance with regard 
    to survival as response: in extensive disease, responding and 
    stable patients had median survival (MST) of 26 weeks from 
    start of therapy, while MST for non-responders was 9 weeks. 
    MST in limited disease (all patients responding or stable) was 
    32 weeks. Analysis of survival in extensive disease by 
    performance status showed improvement in each category over 
    historical control results for supportive care alone. BACON 
    was better tolerated and probably more effective when CCNU was 
    given every 8 weeks, rather than every 4 weeks. 

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