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Cancer Chemotherapy Regimen for Non-small Cell Lung Cancer

  cytoxan......... 300 mg/sqm IV on days 1 and 8.
  adriamycin...... 20 mg/sqm IV on days 1 and 8.
  methotrexate.... 15 mg/sqm IV on days 1 and 8.
  procarbazine.... 100 mg/day orally for 10 days.
  FREQUENCY....... Repeat cycle every 28 days.

    Bitran JD.  Desser RK.  DeMeester TR.  Colman M.  Evans R. 
    Billings A.  Griem M.  Rubenstein L.  Shapiro C.  Golomb HM. 
    Cyclophosphamide, adriamycin, methotrexate, and procarbazine 
    (CAMP)--effective four-drug combination chemotherapy for 
    metastatic non-oat cell bronchogenic carcinoma. Cancer 
    Treatment Reports.  60(9):1225-30, 1976 Sep. 
    Twenty-three patients with metastatic non-oat cell 
    bronchogenic carcinoma (MNOBC) were treated with 
    cyclophosphamide, adriamycin, methotrexate, and procarbazine 
    (CAMP) after radiation therapy. Objective responses were seen 
    in 11 of 23 patients (48%) with a projected median survival 
    time of 12.5 months for responding patients and patients with 
    stable disease. Lung, liver, and cutaneous sites of 
    involvement proved to be highly responsive; bone involvement 
    was less responsive. CAMP is an effective combination in the 
    treatment of MNOBC and its use in patients with less advanced 
    disease should be explored. 

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