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Date of last update: 9/5/2017.

Forum Name: Pharmacy & Drug Topics

Question: lexapro trazodone wellbutrin SR interaction

 bobbie676 - Sat Mar 13, 2004 1:49 am

[size=24]I am on three meds for depression . They are lexapro, trazodone,& wellbutrin SR. :?: are these three meds. able to be taken all together?
 Dr. Tamer Fouad - Sat Mar 13, 2004 3:23 am

User avatar I am not a psychiatrist, I am not aware of the literature concerning combination antidepressants. Your physician would be the best to judge that.
However, from a purely pharmacological point of view combining a SSRI antidepressants (lexapro) with a serotonin antagonist (trazodone) will probably result in elevated blood levels of trazodone and its metabolite (mCPP) may increase and cause anxiety. The combination of SSRI antidepressants with Wellbutrin (bupropion) carries a risk of seizures.

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