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Forum Name: Pharmacy & Drug Topics

Question: N-acetylcysteine with Acetaminophen?


 MuzicLov3r - Tue Mar 11, 2008 1:01 pm

If I took the reccommended dosage of N-acetylcysteine with an higher than normal dose of Acetaminophen (Tylenol), would the N-acetylcysteine help cushion the liver and prevent hepatotoxicity?
 Dr. Chan Lowe - Tue Mar 11, 2008 7:57 pm

User avatar Hello MuzicLov3r,

N-acetylcysteine (NAC) is a compound that is used when too much tylenol has been ingested to help prevent liver damage. Basically, it helps prevent the tylenol from being metabolized via a secondary pathway that creates a metabolite toxic to the liver.

In theory, taking NAC at the same time as the tylenol could potentially help prevent damage from too much tylenol; however, this cannot be guaranteed. In addition, I would strongly recommend against a patient using NAC to be able to take a larger dose of tylenol than is approved/appropriate. The side effects and the actual outcomes can potentially be different than expected and liver damage cannot be absolutely predictably prevented.

Best wishes.

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