Name: Fluoxetine hydrochloride
Pregnancy Category C
Drug classes of Fluoxetine
Mechanism of action of Fluoxetine
Acts by inhibiting CNS neuronal uptake of serotonin leading to increased levels of serotonin in the brain. It has little effect on norepinephrine and dopamine.
Indications of Fluoxetine
Treatment of depression; most effective in patients with major depressive disorder
Contraindications of Fluoxetine
Concomitant use in patients taking monoamine oxidase inhibitors (MAOIs) is contraindicated.
Contraindicated in the presence of hypersensitivity to fluoxetine; pregnancy.
Adverse effectsof Fluoxetine
- CNS: Headache, nervousness, insomnia, drowsiness, anxiety, tremor, dizziness, lightheadedness, agitation, sedation, abnormal gait, convulsions
- GI: Nausea, vomiting, diarrhea, dry mouth, anorexia, dyspepsia, constipation, taste changes, flatulence, gastroenteritis, dysphagia, gingivitis
- CV: Hot flashes, palpitations
- Respiratory: Upper respiratory infections, pharyngitis, cough, dyspnea, bronchitis, rhinitis
- GU: Painful menstruation, sexual dysfunction, frequency, cystitis, impotence, urgency, vaginitis
- Dermatologic: Sweating, rash, pruritus, acne, alopecia, contact dermatitis
- Other: Weight loss, asthenia, fever
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