Name: Nefazodone hydrochloride
Pregnancy Category C
Drug classes of Nefazodone
Mechanism of action of Nefazodone
Acts by inhibiting CNS neuronal uptake of serotonin and norepinephrine; also blocks 5-HT2 and apha1 receptors. The drug has no significant affinity for alpha1, beta-adrenergic, 5-HT1A, cholinergic, dopaminergic or benxodiazipine receptors.
Indications of Nefazodone
Treatment of depression
Contraindications of Nefazodone
- Contraindicated in the presence of hypersensitivity to nefazodone; related compounds (phenylpiperazines).
- Contraindicated in the presence of impaired hepatic or renal function.
- Should not be taken concurrently with MAO inhibitors. MAO inhibitors can only be initiated 7 days after discontinuation of serotonin reuptake inhibitors.
- Concurrent use with astemizole, carbamazipine, cisapride or pimozide, triazolam or alprazolam.
Adverse effectsof Nefazodone
- CNS: Headache, nervousness, insomnia, drowsiness, anxiety, dizziness, agitation
- GI: Nausea, xerostomia, constipation
- CV: Bradycardia, hypotension, peripheral edema, palpitations
- Endocrine: Breast pain, decreased libido, impotence
- Neuromuscular & skeletal: Weakness
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