Back to Serotinine Reuptake Inhibitors

Name: Serzone hydrochloride

Pregnancy Category C

Drug classes of Serzone

Mechanism of action of Serzone

Acts by inhibiting CNS neuronal uptake of serotonin and norepinephrine; also blocks 5-HT2 and apha1 receptors. The drug has no significant affinity for alpha1, beta-adrenergic, 5-HT1A, cholinergic, dopaminergic or benxodiazipine receptors.

Indications of Serzone

Treatment of depression

Contraindications of Serzone

Contraindicated in the presence of hypersensitivity to Serzone; related compounds (phenylpiperazines).
Contraindicated in the presence of impaired hepatic or renal function.
Should not be taken concurrently with MAO inhibitors. MAO inhibitors can only be initiated 7 days after discontinuation of serotonin reuptake inhibitors.
Concurrent use with astemizole, carbamazipine, cisapride or pimozide, triazolam or alprazolam.

Adverse effectsof Serzone

CNS: Headache, nervousness, insomnia, drowsiness, anxiety, dizziness, agitation
GI: Nausea, xerostomia, constipation
CV: Bradycardia, hypotension, peripheral edema, palpitations
Endocrine: Breast pain, decreased libido, impotence
Neuromuscular & skeletal: Weakness

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