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Name: Venlafaxine

Pregnancy Category C

Drug classes

Mechanism of action of Venlafaxine

Acts as an antidepressant by inhibiting CNS neuronal uptake of serotonin; blocks uptake of serotonin and norepinephrine with a weak inhibitory effect on dopamine reuptake.

Indications of Venlafaxine

Treatment of depression and generalized anxiety disorder.

Contraindications of Venlafaxine

Adverse Reactionsof Venlafaxine

  • CNS: Headache, somnolence, dizziness, insomnia, nervousness.
  • GIT: Nausea, xerostomia, constipation, anorexia.
  • Genitourinary: Abnormal ejaculation / orgasm.
  • Neuromuscular & skeletal: weakness.
  • Other: diaphoresis


Toxicity from the drug is not lethal & can be tolerated with supportive therapy.

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