Brand Name: Zoloft
Name: Sertraline hydrochloride
Pregnancy Category C
Mechanism of action of Zoloft
Acts as an antidepressant by inhibiting CNS neuronal uptake of serotonin;
which raises serotonin levels in the CNS with little effect on norepinephrine, muscarinic, histaminergic, and alpha1-adrenergic or dopaminergic receptors.
Indications of Zoloft
Treatment of depression
Unlabeled use: treatment of obsessive-compulsive disorders
Contraindications of Zoloft
Contraindicated in the presence of hypersensitivity to Zoloft; pregnancy.
Use caution in the presence of impaired hepatic or renal function, lactation.
Adverse effectsof Zoloft
- CNS: Headache, nervousness, drowsiness, anxiety, tremor, dizziness, insomnia lightheadedness, agitation, sedation, abnormal gait, convulsions, vision changes, fatigue
- GI: Nausea, vomiting, diarrhea, dry mouth, anorexia, dyspepsia, constipation, taste changes, flatulence, gastroenteritis, dysphagia, gingivitis
- CV: Palpitations, chest pain
- Respiratory: Upper respiratory infections, pharyngitis, cough, dyspnea, bronchitis, rhinitis
- GU: Painful menstruation, sexual dysfunction, frequency, cystitis, impotence, urgency, vaginitis
- Dermatologic: Sweating, rash, pruritus, acne, contact dermatitis
- Other: Hot flushes, fever, back pain, thirst
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