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Date of last update: 8/24/2017.

Forum Name: Antidepressants

Question: Effexor and weight gain

 pain in the sunshine stat - Wed Dec 14, 2005 1:39 pm

I have been on Effexor XR for over a year I am taking 225 mg, my diet has not changed and I am active. I do not have a routine excercise plan, but I never had one either. I have blown up in my belly midsection. Can Wellbutrin by perscribed with Effexor XR?
 Dr. Tamer Fouad - Thu Dec 15, 2005 1:12 am

User avatar Venlafaxine (Effexor), a potent inhibitor of serotonin and norepinephrine reuptake, is sometimes prescribed for patients with psychomotor retardation, hypersomnia, or resistance to other antidepressants.[1] A short-term study comparing venlafaxine (Effexor) with fluoxetine (Prozac) found no significant weight gain with either agent.[2] Thus, like SSRIs and unlike mirtazapine, venlafaxine (Effexor) is less likely to cause weight gain in the short term,[3] although there are not enough data to comment on its long-term effects.

You will need to discuss the possibility of changing your medication with your psychiatrist.

1. Stahl SM. Psychopharmacology of antidepressants. London, UK: Dunitz 1998.
2. Silverstone PH, Ravindran A. Once daily venlafaxine extended release compared with fluoxetine in outpatients with depression and anxiety. Venlafaxine XR 360 Study Group. J Clin Psychiatry 1999; 60:22–28.
3. Guelfi JD, Ansseau M, Timmerman L, Korsgaard S. Mirtazapine vs venlafaxine in hospitalized severely depressed patients with melancholic features. Mirtazapine-Venlafaxine Study Group. J Clin Psychopharmacol 2001; 21:425–431.

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