Medical Specialty >> Psychiatry

Doctors Lounge - Psychiatry Answers

Back to Psychiatry Answers List

If you think you may have a medical emergency, call your doctor or 911 immediately. Doctors Lounge ( does not recommend or endorse any specific tests, physicians, products, procedures, opinions, or other information that may be mentioned on the Site.

DISCLAIMER: The information provided on is designed to support, not replace, the relationship that exists between a patient/site visitor and his/her physician. Please read our 'Terms and Conditions of Use' carefully before using this site.

Date of last update: 8/24/2017.

Forum Name: Antidepressants

Question: Wellbutrin + Depakote for Bipolar II...a few questions

 jandot - Wed May 30, 2007 8:12 pm

I have been on depakote for three and a half months. After two months of being on it, my doctor started me on Prozac. After being on the Prozac for a month, I felt completely lifeless, and I had no energy. After telling my doctor this, he took me off Prozac, and then decided to start me on wellbutrin after a two week wait. So, ive begun taking the wellbutrin just recently and I have a few questions...

My doctor told me to take 75 mg's a day, but everywhere I look on the internet says that 300-400 mg's a day is required for Depression, and there never seems to be any mention of it being a gradual process to get to that level. Does the fact that I'm mixing this with depakote mean that I should be taking less? Isnt taking 75 mg of something that usually starts out at 300 mg kind of pointless?

 Dr. K. Eisele - Sun Jun 03, 2007 12:39 pm

User avatar Dear JanDot:

There are no known drug-drug interactions between Depakote and Wellbutrin. However, there is a potentially very serious drug-disease interaction between Wellbutrin and Bipolar Disorder. It is generally felt to be safe for people with this illness to take Wellbutrin, but in lower doses than a patient with another disorder would typically require.

Good luck to you!

| Check a doctor's response to similar questions

Are you a Doctor, Pharmacist, PA or a Nurse?

Join the Doctors Lounge online medical community

  • Editorial activities: Publish, peer review, edit online articles.

  • Ask a Doctor Teams: Respond to patient questions and discuss challenging presentations with other members.

Doctors Lounge Membership Application

Tools & Services: Follow DoctorsLounge on Twitter Follow us on Twitter | RSS News | Newsletter | Contact us