Medical Specialty >> Psychiatry

Doctors Lounge - Psychiatry Answers

Back to Psychiatry Answers List

If you think you may have a medical emergency, call your doctor or 911 immediately. Doctors Lounge ( does not recommend or endorse any specific tests, physicians, products, procedures, opinions, or other information that may be mentioned on the Site.

DISCLAIMER: The information provided on is designed to support, not replace, the relationship that exists between a patient/site visitor and his/her physician. Please read our 'Terms and Conditions of Use' carefully before using this site.

Date of last update: 8/24/2017.

Forum Name: Antidepressants

Question: Trazadone Side-Effects

 equijames - Wed Mar 25, 2009 6:05 pm

I have been on 50mg of trazadone for my insomnia for the past couple of weeks. Recently i have felt a tremendous amount of dissociation (feelings like i was very removed from my body, or if my arms and legs did not belong to me) I have felt dissociation before, but that was years ago during the height of my panic disorder. I went on Paxil and after a while most of the feelings of dissociation went away. I got off of paxil (was on it for 4 years) and several months later i began to have insomina. The doctors tried everything, but trazadone works the best. I sleep right through the night. The problem is the heightened dissociation. i have read some forums where doctors have taken thier patients off of trazadone because of increased dissocation, but the information is scant and the sources are unreliable. Of course, I´m going to talk to my doctor about this but i want to hear from another source. Can trazadone increase dissociation, even if only rarely? Or is the source something different. I was prescribed Amitryptiline before trazadone to help me sleep and the more i took the more anxious i got. I know that amitryptiline is in the same class as trazadone so i´m guessing the increased anxiety might be causing me to feel this dissociation, but i´m not a doctor, and so that could be just some phony theory of mine.

all the best
 Dr. E. Seigle - Fri Apr 17, 2009 8:25 am

Hi equijames,

I have not seen people have dissociation from trazodone, though it is possible. It seems possible that when you stopped taking Paxil (and started the trazodone), your pre-existing dissociation (which you reported occurred along with panic attacks), returned. The cause may have been stopping the Paxil, rather than an effect of the trazodone. Are you also having panic attacks again? This would tend to point toward the stopping of the Paxil, as well. In general, trazodone is not used as an anti-anxiety medication, including an anti-panic medication. I agree it would be a good idea to discuss this further with your regular doctor. Good luck!

E. Seigle MD

| Check a doctor's response to similar questions

Are you a Doctor, Pharmacist, PA or a Nurse?

Join the Doctors Lounge online medical community

  • Editorial activities: Publish, peer review, edit online articles.

  • Ask a Doctor Teams: Respond to patient questions and discuss challenging presentations with other members.

Doctors Lounge Membership Application

Tools & Services: Follow DoctorsLounge on Twitter Follow us on Twitter | RSS News | Newsletter | Contact us