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Brand Name: N-Acetyl-P-Aminophenol
Name: Acetaminophen

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Pregnancy Category B

Drug classes
Antipyretic
Analgesic (non-narcotic)

Mechanism of action of N-Acetyl-P-Aminophenol
Inhibits the synthesis of prostaglandins in the central nervous system and peripherally blocks pain impulse generation; produces antipyresis from inhibition of hypothalamic heat-regulating center.

Indications of N-Acetyl-P-Aminophenol

  1. Analgesic-antipyretic in patients with aspirin allergy, hemostatic disturbances, bleeding diatheses, upper GI disease, gouty arthritis
  2. Arthritis and rheumatic disorders involving musculoskeletal pain (but lacks clinically significant antirheumatic and anti- inflammatory effects)
  3. Common cold, "flu," other viral and bacterial infections accompanied by pain and fever
  4. Unlabeled use: prophylactic for children receiving DPT vaccination to reduce incidence of fever and pain

Contraindications of N-Acetyl-P-Aminophenol

  1. Contraindicated in the presence of allergy to N-Acetyl-P-Aminophenol.
  2. Use caution in the presence of impaired hepatic function, chronic alcoholism, pregnancy, lactation.

Adverse effects of N-Acetyl-P-Aminophenol

Negligible with recommended dosage.

  • CNS: Headache
  • GI: Hepatic toxicity and failure, jaundice
  • CV: Chest pain, dyspnea, myocardial damage when doses of 5-8 g/d are ingested daily for several weeks or when doses of 4 g/d are ingested for 1 year
  • Hematologic: Methemoglobinemia-cyanosis; hemolytic anemia-hematuria, anuria; neutropenia, leukopenia, pancytopenia, thrombocytopenia, hypoglycemia
  • GU: Acute kidney failure, renal tubular necrosis
  • Hypersensitivity reactions: Skin rash, fever Treatment of overdose: Monitor serum levels regularly, N- acetylcysteine should be available as a specific antidote; basic life support measures may be necessary.

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