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Back to Narcotic Analgesics

Name: Propoxyphene hydrochloride

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Pregnancy Category C

C-IV controlled substance

Drug classes

Narcotic agonist analgesic

Therapeutic actions

Acts as agonist at specific opioid receptors in the CNS to produce analgesia, euphoria, sedation; the receptors mediating these effects are thought to be the same as those mediating the effects of endogenous opioids (enkephalins, endorphins).


Relief of mild to moderate pain


Contraindicated in the presence of hypersensitivity to narcotics, pregnancy (neonatal withdrawal has occurred in infants born to mothers who used narcotics during pregnancy; safety for use in pregnancy not
established), labor or delivery (especially when delivery of a premature
infant is expected; administration of narcotics to the mother can cause
respiratory depression of neonate; may prolong labor), lactation.

Use caution in the presence of renal or hepatic dysfunction, emotional depression.

Adverse effects

  • CNS: Dizziness, sedation, lightheadedness, headache, weakness, euphoria, dysphoria, minor visual disturbances
  • GI: Nausea, vomiting, constipation, abdominal pain, liver dysfunction
  • Dermatologic: Skin rashes
  • Other: Tolerance and dependence, psychological dependence

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