Brand Name: Brufen
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Pregnancy Category B
Mechanism of action of Brufen
Anti-inflammatory, analgesic, and antipyretic activities largely related to inhibition of prostaglandin synthesis; exact mechanisms of action are not known.
Indications of Brufen
- Relief of signs and symptoms of rheumatoid arthritis and osteoarthritis
- Relief of mild to moderate pain
Treatment of primary dysmenorrhea
- Fever reduction
- Unlabeled use: treatment of juvenile rheumatoid arthritis
Contraindications of Brufen
- Presence of allergy to ibuprofen, salicylates, or other NSAIDs (more common in patients with rhinitis, asthma, chronic urticaria, nasal polyps)
- Cardiovascular dysfunction
- Peptic ulceration
- GI bleeding
Use caution in the presence of impaired hepatic or renal function.
Adverse effects of Brufen
- CNS: Headache, dizziness, somnolence, insomnia, fatigue, tiredness, dizziness, tinnitus, ophthalmologic effects
- GI: Nausea, dyspepsia, GI pain, diarrhea, vomiting, constipation, flatulence
- Respiratory: Dyspnea, hemoptysis, pharyngitis, bronchospasm, rhinitis
- Hematologic: Bleeding, platelet inhibition with higher doses, neutropenia, eosinophilia, leukopenia, pancytopenia, thrombocytopenia, agranulocytosis, granulocytopenia, aplastic anemia, decreased hemoglobin or hematocrit, bone marrow depression, menorrhagia
- GU: Dysuria, renal impairment
- Dermatologic: Rash, pruritus, sweating, dry mucous membranes, stomatitis
- Other: Peripheral edema, anaphylactoid reactions to fatal anaphylactic shock
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