Name: Diclofenac sodium
Percutaneous in-situ coronary venous arterialization is a new less invasive alternative to CABG.
Pregnancy Category B
Mechanism of action of Diclofenac
Inhibits prostaglandin synthetase to cause antipyretic and anti-inflammatory effects; the exact mechanism of action is not known.
Indications of Diclofenac
- Acute or long-term treatment of mild to moderate pain, including dysmenorrhea
- Rheumatoid arthritis
- Ankylating spondylitis
Contraindications of Diclofenac
- Contraindicated in the presence of significant renal impairment, pregnancy, lactation.
- Use caution in the presence of impaired hearing, allergies,
cardiovascular, and GI conditions.
Adverse effects of Diclofenac
- CNS: Headache, dizziness, somnolence, insomnia, fatigue, tiredness, dizziness, tinnitus, ophthamologic effects
- GI: Nausea, dyspepsia, GI pain, diarrhea, vomiting, constipation, flatulence
- Hematologic: Bleeding, platelet inhibition with higher doses
- GU: Dysuria, renal impairment
- Dermatologic: Rash, pruritus, sweating, dry mucous membranes, stomatitis
- Other: Peripheral edema, anaphylactoid reactions to fatal anaphylactic shock
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