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Date of last update: 8/21/2017.

Forum Name: Rheumatology Topics

Question: Methotrexate muscle pain

 dbacs - Tue Jan 24, 2006 4:10 am

I have just recently been put on Methotrexate for autoimmune hearing loss and chronic urticaria.

Within two weeks of my first dose, which i take once a week, i have been having severe muscle pain when excersizing for more than 5 minutes. Normally i can excercize for more than an hour non-stop. I also play hockey 2 days a week.

I get this pain in my calves and in my back. It gets so bad that i can't feel my feet and i get extremely week and almost collapse. It feels like a charlie horse (?). Over worked muscles?

This has never happened before on any of my pervious NSAIDS or medrol.

Does methotrexate cause muscle pain?

What can i do about this if it does?
 Theresa Jones, RN - Tue Jan 24, 2006 11:23 am

User avatar Hi dbacs,
Although muscle pain is not one one of the specificly reported adverse effects of Methotrexate, there are documented links to cardiovascular side effects, such as, hypotension,
thromboembolic events, etc. I would strongly suggest that you notify your physician since your symptoms have had an abrupt onset since initiating this therapy.
Theresa Jones, RN
 dbacs - Tue Jan 24, 2006 8:03 pm

Thank you I will contact him. That sounds nasty and dangerous. :(

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