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Date of last update: 8/21/2017.

Forum Name: Rheumatology Topics

Question: Methotrexate - lowering the dose

 bumblebuzzbee - Wed Oct 21, 2009 9:57 am

I have been taking methotrexate for my RA for nearly 3 years now and find that this along with Brufen Retard nightly keeps most of my pain at bay other than the odd "flare up"

When I first started taking methotrexate I didnt drink alcohol at all as I didnt go out much and the last year or so I have done and Ive been out drinking. My Consultant has advised that its ok for me to do this in moderation but sometimes I don't and so I tend not to take my Methotrexate for a couple of weeks to give my liver a rest. As this doesnt cause me too much trouble apart from the odd twinge I would like to discuss with my Consultant about getting my MXT dosage down and maybe use another alternative drug to support it. Would Glucosomine be a good one to help support a lower does of MXT or is there another remedy that might do the job?

AS you can imagine Im not keen to discuss with my consoltant that I miss doses of my MXT as I know she wont be impressed.
 Tom Plamondon PA-C - Sun Oct 25, 2009 9:11 pm

User avatar Hello,
Ethanol with methotrexate increases the risk or rate of liver injury so do not mix the two.
Half the people I talk to report joint pain benefit with glucosamine chondroitin...the other half report no benefit.
Other than NSAIDS, you may discuss other RA treatments...these would be more aggressive than MTX. Still, avoid combination of alcohol consumption with DMARDS (disease modifying anti rheumatoid drugs) is wise.

Take care.

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